Cholesterol in Food – How it Gets in Your Blood.

I was talking to my wife the other day about cholesterol in food and its effects on blood levels. I found the following article:

“Eat a low-fat, low-cholesterol diet” has been the mantra for healthful eating for decades. Touted as a way to lose weight and prevent or control heart disease and other chronic conditions, millions of people have followed (or, more likely, have tried to follow) this advice. Seeing a tremendous marketing opportunity, food companies re-engineered thousands of foods to be lower in fat or fat free. The low-fat approach to eating may have made a difference for the occasional individual, but as a nation it hasn’t helped us control weight or become healthier. In the 1960s, fats and oils supplied Americans with about 45 percent of their calories;  about 13 percent of us were obese and under 1 percent had type 2 diabetes, a serious weight-related condition.  Today, Americans take in less fat, getting about 33 percent of calories from fats and oils;  yet 34 percent of us are obese and 8 percent have diabetes, most with type 2 diabetes.

Why hasn’t cutting fat from the diet paid off as expected? Detailed research—much of it done at Harvard—shows that the total amount of fat in the diet isn’t really linked with weight or disease. What really matters is the type of fat in the diet. Bad fats, meaning trans and saturated fats, increase the risk for certain diseases. Good fats, meaning monounsaturated and polyunsaturated fats, do just the opposite. They are good for the heart and most other parts of the body.

What about cholesterol in food? For most people, the mix of fats in the diet influences cholesterol in the bloodstream far more than cholesterol in food does.

From Food to the Bloodstream

Almost all foods contain some fat. Even quintessential fat-free foods like carrots and lettuce contain small amounts of this nutrient. That’s a testament to how important fats are for life. Fat provides a terrific source of energy as well as a great depot for storing it. It is an important part of cell membranes, helping govern what gets into cells and what comes out. The body uses cholesterol as the starting point to make estrogen, testosterone, vitamin D, and other vital compounds. Fats are also biologically active molecules that can influence how muscles respond to insulin’s “open up for sugar” signal; different types of fats can also fire up or cool down inflammation.

Fat and cholesterol can’t dissolve in water or blood. The body gets around this basic chemistry problem by packaging fat and cholesterol into tiny, protein-covered particles called lipoproteins. Although lipoproteins can carry quite a bit of fat, they mix easily with blood and flow with it. Some of these particles are big and fluffy, others small and dense. The most important ones are low-density lipoproteins, high-density lipoproteins, and triglycerides.

Q. What can I do to lower my total cholesterol and LDL?

A. Several strategies can help you lower the amounts of total and harmful LDL cholesterol in your bloodstream, and thus your risk of heart disease

  • Low-density lipoproteins (LDL) carry cholesterol from the liver to the rest of the body. Cells latch onto these particles and extract fat and cholesterol from them. When there is too much LDL cholesterol in the blood, these particles can form deposits in the walls of the coronary arteries and other arteries throughout the body. Such deposits, called plaque, can narrow arteries and limit blood flow. When plaque breaks apart, it can cause a heart attack or stroke. Because of this, LDL cholesterol is often referred to as bad, or harmful, cholesterol.
  • High-density lipoproteins (HDL) scavenge cholesterol from the bloodstream, from LDL, and from artery walls and ferry it back to the liver for disposal. Think of HDL as the garbage trucks of the bloodstream. HDL cholesterol is often referred to as good, or protective, cholesterol.
  • Triglycerides make up most of the fat that you eat and that travels through the bloodstream. As the body’s main vehicle for transporting fats to cells, triglycerides are important for good health. But as is the case for so many things, an excess of triglycerides can be unhealthy.

In general, the lower your LDL and the higher your HDL, the better your chances of preventing heart disease and other chronic conditions. Guidelines from the National Cholesterol Education Program suggest specific targets.

How Fat and Cholesterol in Food Affect Blood Levels

The types of fat in the diet determine to a large extent the amount of total and LDL cholesterol in the bloodstream. Cholesterol in food matters, too, but not nearly as much.

Good Fats

Unsaturated fats are called good fats because they can improve blood cholesterol levels, ease inflammation, stabilize heart rhythms, and play a number of other beneficial roles. Unsaturated fats are predominantly found in foods from plants, such as vegetable oils, nuts, and seeds. They are liquids at room temperature.

There are two types of unsaturated fats:

  • Monounsaturated fats are found in high concentrations in canola, peanut, and olive oils; avocados; nuts such as almonds, hazelnuts, and pecans; and seeds such as pumpkin and sesame seeds.
  • Polyunsaturated fats are found in high concentrations in sunflower, corn, soybean, and flaxseed oils, and also in foods such as walnuts, flax seeds, and fish. Omega-3 fats, which are fast becoming the darling of the supplement industry, are an important type of polyunsaturated fat. The body can’t make these, so they must come from food. An excellent way to get omega-3 fats is by eating fish two or three times a week. Good plant sources of omega-3 fats include chia seeds (sold as Salvia), flax seeds, walnuts, and oils such as flaxseed, canola, and soybean.

Dutch researchers conducted an analysis of 60 trials that examined the effects of carbohydrates and various fats on blood lipid levels. In trials in which polyunsaturated and monounsaturated fats were eaten in place of carbohydrates, these good fats decreased levels of harmful LDL and increased protective HDL.  More recently, a randomized trial known as the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart) showed that replacing a carbohydrate-rich diet with one rich in unsaturated fat, predominantly monounsaturated fats, lowers blood pressure, improves lipid levels, and reduces the estimated cardiovascular risk.

Most people don’t get enough of these healthful unsaturated fats each day. No strict guidelines have been published regarding their intake. Prudent targets are 10 to 25 percent of calories from monounsaturated fats and 8 to 10 percent of calories from polyunsaturated fats. Since no one eats by percentage of daily calories, a good rule of thumb is to choose unsaturated fats over saturated whenever possible.

Bad Fats

Our bodies can make all the saturated fat we need, so we don’t need to eat any of it. That’s why saturated fat can be in the bad category—because we don’t need to eat any of it, and it has undesirable effects in cardiovascular disease. In the United States and other developed countries, saturated fats come mainly from meat, seafood, and whole-milk dairy products (cheese, milk, and ice cream). A few plant foods are also high in saturated fats, including coconut and coconut oil, palm oil, and palm kernel oil. Saturated fats boost total cholesterol by elevating harmful LDL. Like all dietary fat, saturated fat also raises the protective HDL. Unsaturated fat is much preferable since it lowers the bad cholesterol and raises the good.

As a general rule, it’s a good idea to keep your intake of saturated fats as low as possible. Saturated fats are part of many foods, including vegetable oils that are mainly unsaturated fats, so we can’t eliminate them from our diets. Seven percent of total calories or lower is a good target. Red meat and dairy fats are the main sources of saturated fat in our diets, so keeping these low is the primary way to reduce intake of saturated fat.

Very Bad Fats

Trans fatty acids, more commonly called trans fats, are made by heating liquid vegetable oils in the presence of hydrogen gas, a process called hydrogenation. Partially hydrogenating vegetable oils makes them more stable and less likely to spoil. It also converts the oil into a solid, which makes transportation easier. Partially hydrogenated oils can also withstand repeated heating without breaking down, making them ideal for frying fast foods. (Fully hydrogenating a vegetable oil creates a fat that acts like a saturated fat.) It’s no wonder that partially hydrogenated oils have been a mainstay in restaurants and the food industry.

Most of the trans fats in the American diet come from commercially prepared baked goods, margarines, snack foods, and processed foods, along with French fries and other fried foods prepared in restaurants and fast food franchises.

Trans fats are worse for cholesterol levels than saturated fats because they raise bad LDL and lower good HDL. They also fire inflammation, (12) an overactivity of the immune system that has been implicated in heart disease, stroke, diabetes, and other chronic conditions. Even small amounts of trans fat in the diet can have harmful health effects. For every extra 2 percent of calories from trans fat daily—about the amount in a medium order of fast-food French fries—the risk of coronary heart disease increases by 23 percent. Eliminating trans fats from the U.S. food supply could prevent between 6 and 19 percent of heart attacks and related deaths, or more than 200,000 each year.

The average American eats about six grams of trans fats a day. Ideally that should be under two grams a day, or zero if possible. A new labeling law that forces food companies to list trans fats on the label should help curb the consumption of these harmful fats. Not only can consumers now see which products contain trans fats—something that wasn’t easily done in the past—but many food makers are now trying to claim the high ground by using trans-free oils and fats in their products.

As trans fat intake dwindles in developed countries, it is on the rise in developing nations. Inexpensive partially hydrogenated soybean oil has become a staple not only for the food industry but for home use. This shift away from traditional cooking oils and toward trans-rich partially hydrogenated oils is contributing to the slowly growing epidemic of cardiovascular disease in developing nations around the world.

The discovery half a century ago that high blood cholesterol levels were strongly associated with an increased risk for heart disease triggered numerous warnings to avoid foods that contain cholesterol, especially eggs, liver, shrimp, and lobster. That advice was something of a red herring; for example eating shrimp and lobster doesn’t raise LDL cholesterol. Also, most people make more cholesterol than they absorb from their food. A body of scientific studies shows only a weak relationship between the amount of cholesterol a person consumes and his or her blood cholesterol levels (weak but important for heart disease). In studies of more than 80,000 female nurses, Harvard researchers found that consuming about an egg a day was not associated with higher risk of heart disease (too few women in the study were eating more than an egg a day to evaluate the effects of higher egg intakes).  One note of caution: Among women in this study with diabetes and in another study of men with diabetes, higher egg consumption has been associated with increased risks of heart disease.

Dietary Fats and Heart Disease: Beyond the “30 Percent” Recommendation

For years, the party line from the American Heart Association, National Institutes of Health, World Health Organization, and others was to reduce dietary fat. They generally called for limiting fat intake to under 30 percent of daily calories. One problem with a generic lower fat diet is that it prompts most people to stop eating fats that are good for the heart along with those that are bad for it. In place of fats, many people turn to foods full of easily digested carbohydrates, or to fat-free products that replace healthful fats with sugar and refined carbohydrates.

There wasn’t much evidence to support the notion of low-fat diets in the beginning.  There is even less now. Numerous reports over the years have questioned the wisdom of recommending low-fat diets for preventing or retarding heart disease. A big nail in the coffin came from the Women’s Health Initiative Dietary Modification Trial, published in the February 8, 2006, Journal of the American Medical Association.  This eight-year trial, which included almost 49,000 women, found virtually identical rates of heart attack, stroke, and other forms of cardiovascular disease in women who followed a low-fat diet and in those women who didn’t. What’s more, women on the low-fat diet didn’t lose—or gain—any more weight than women who followed their usual diets.

This randomized trial supports prior findings from the Nurses’ Health Study and the Health Professionals Follow-up Study.  In both of these, no link was seen between the overall percentage of calories from fat and any important health outcome, including cancer, heart disease, and weight gain.

What was important in these studies was the type of fat in the diet.  Ounce for ounce, trans fats are far worse than saturated fats when it comes to heart disease. In the Nurses’ Health Study, replacing just 30 calories of carbohydrates (7 grams) every day with 30 calories of trans fats (4 grams) nearly doubled the risk for heart disease.  Saturated fats increased the risk as well, but not nearly as much.

For good fats, there is consistent evidence that higher intake of either monounsaturated or polyunsaturated fat (especially the latter) lowers the risk for heart disease. In the Nurses’ Health Study, replacing 80 calories of carbohydrates with 80 calories of either polyunsaturated or monounsaturated fats lowered the risk for heart disease by about 30 to 40 percent.

Dietary Fat and Obesity

It is a common belief that the more fat you eat, the more weight and body fat you gain. This belief has been bolstered by much of the nutrition advice given to people over the past few decades, which has focused on lowering total fat intake while increasing carbohydrate intake. But the notion that food fat equals body fat isn’t completely true, and the advice has been misguided. For example, while Americans have gradually decreased the proportion of calories they get from fat over the past few decades, rates of obesity have increased steeply.

Over the short term, following a low-fat diet does lead to weight loss. But so does following a high-fat, low-carbohydrate diet. Or a high-protein, low-carbohydrate diet. Actually, almost any diet that helps you take in fewer calories works over the short term. In other words, for most people low-fat diets offer no apparent advantages over diets with fat levels close to the national average. This was demonstrated in the Women’s Health Initiative Dietary Modification Trial. Women in this trial who were assigned to a low-fat diet did not lose, or gain, more weight than women eating a “usual” diet.

Although more research is needed, a prudent recommendation for losing weight or maintaining a healthy weight is to be mindful of the amount of food you eat in relation to the amount of calories you burn in a day. A moderate intake of fats, with an emphasis on healthful unsaturated fats, fits in fine with a weight-loss or weight-maintaining diet.

via Fats and Cholesterol: Out with the Bad, In with the Good – What Should You Eat? – The Nutrition Source – Harvard School of Public Health.